JPC-3210
JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC50 ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1609655-35-7
- 分子式: C21H26F4N2O
- 分子量:398.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
化学情報
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CAS 番号 1609655-35-7
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分子量 398.44
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分子式 C21H26F4N2O
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SMILES
OC1=C(C2=CC(F)=C(C(F)(F)F)N=C2)C=C(C(C)(C)C)C=C1CNC(C)(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Birrell, G. W., et al., (2020). Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum. Molecular & cellular proteomics : MCP, 19(2), 308-325. [Content Brief]
[2]. Birrell, G. W., et al., (2018). Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 62(4), e01335-17. [Content Brief]
[3]. Chavchich, M., et al., (2016). Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 60(5), 3115-3118. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JPC-3210 関連分類
HY-117599 関連分類
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