Jun13698
Jun13698 is a SARS-CoV-2 main protease (Mpro) inhibitor with Ki values of 65.6 nM, 510.0 nM, and 117.5 nM against the wild-type, E166V, and E166A mutants, respectively. Jun13698 forms stable complexes with wild-type and mutant Mpro to mediate enzyme inhibition. Jun13698 exhibits antiviral activity against SARS-CoV-2 variants carrying the E166V/A mutation. Jun13698 is applicable to COVID-19-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H30F3N3O4S
- 分子量:465.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Jun13698 potently inhibits wild-type and Nirmatrelvir (HY-138687)-resistant recombinant SARS-CoV-2 in Vero E6 cells, with an rWT EC50 of 0.08 μM and EC50 values ranging from 0.20 μM to 1.01 μM against the mutant strains. It shows no cytotoxicity even at concentrations as high as 250 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 465.53
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分子式 C20H30F3N3O4S
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SMILES
O=C([C@@H]1[C@@]2([H])C(C)(C)[C@@]2([H])CN1C([C@H](C(C)C)NC(C(F)(F)F)=O)=O)N[C@@H](CCSC)C=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Jun13698 関連分類
HY-181263 関連分類
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