Jun16229
Jun16229 is a covalent inhibitor of CHIKV nsP2 cysteine protease (IC50 0.27 μM). Jun16229 exhibits anti-CHIKV activity. Jun16229 shows broad-spectrum antiviral activity against ONNV, MAYV, and RRV.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H16FN3O4S
- 分子量:401.41
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
2.2 μM
|
Antiviral activity against CHIKV 181/25 in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 72 hrs by neutral red staining.
Antiviral activity against CHIKV 181/25 in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 72 hrs by neutral red staining.
|
42720489 |
| Vero | CC50 |
25.5 μM
|
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red staining.
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red staining.
|
42720489 |
| Vero | EC50 |
0.93 μM
|
Inhibition of CHIKV plaque formation in african green monkey Vero cells incubated for 72 hrs by crystal violet staining.
Inhibition of CHIKV plaque formation in african green monkey Vero cells incubated for 72 hrs by crystal violet staining.
|
42720489 |
| Vero | EC50 |
0.94 μM
|
Antiviral activity against ONNV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against ONNV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
|
42720489 |
| Vero | EC50 |
0.56 μM
|
Antiviral activity against MAYV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against MAYV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
|
42720489 |
| Vero | EC50 |
0.59 μM
|
Antiviral activity against RRV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
Antiviral activity against RRV in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining.
|
42720489 |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
分子量 401.41
-
分子式 C19H16FN3O4S
-
SMILES
CS(=O)(/C=C/CNC(C1=CC(C2=NOC(C3=C(C=CC=C3)F)=N2)=CC=C1)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Jun16229 関連分類
HY-189432 関連分類
Powered by Bioz