Kalibor
Based on 1 Customer Validation
Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a boron-based salt and antibacterial agent. Kalibor exerts activity against Neisseria meningitidis and Neisseria gonorrhoeae. Kalibor facilitates boron uptake by Neisseria meningitidis cells. Kalibor reduces bacterial burden in a mouse model of Neisseria meningitidis bacteremia. Kalibor can be used for the research of bacterial infection, such as meningococcal bacteremia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 143-66-8
- 分子式: C24H20BNa
- 分子量:342.22
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保管条件:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-W025784R
Kalibor (Standard)
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HY-W251598C
Sodium bicarbonate, for cell culture
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HY-W251598B
Sodium bicarbonate, for molecular biology
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HY-W279223
Potassium tetrakis(4-chlorophenyl)borate
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HY-W127672
Tetramethylammonium tetrafluoroborate
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HY-W000993
Benzylboronic acid pinacol ester
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HY-W111436
Tetrabutylammonium tetraphenylborate
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HY-W014106
Tetraethylammonium tetrafluoroborate
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HY-W007746
1-Cyclohexeneboronic acid pinacol ester
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HY-20304
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
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HY-W251598I
Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500
生物活性
Kalibor (0-100 μM; 16 h) potently inhibits growth of Neisseria meningitidis isolate LNP24198 with an MIC of 12.5 μM[1].
Kalibor (30-50 μM; 3 h) displays rapid bactericidal activity against Neisseria meningitidis and Neisseria gonorrhoeae, with MBC values of 13 μM and 4 μM, respectively, and eliminates all viable cells at 50 μM[1].
Kalibor (1-100 μM; 8 h) promotes significant boron uptake in pathogenic Neisseria gonorrhoeae and Neisseria meningitidis, with minimal uptake in non-pathogenic Neisseria lactamica and Neisseria elongata at 5 μM, and high uptake but no toxicity in N. elongata at 100 μM[1].
Kalibor (30-75 μM; 3-16 h) reduces susceptibility in Neisseria meningitidis mutants with decreased sodium tetraphenylborate sensitivity, which have 2-3 fold higher MICs (37.5-75 μM) and an MBC of 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Kalibor (20 μM; i.v., i.p.; single dose) does not cause visible toxicity in healthy mice over 4 weeks[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (7-week-old; bacterial meningitis model via injection of luminescent Neisseria meningitidis isolate LNP24198 with human transferrin mixture; influenza virus-meningococcal coinfection)[1]
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Dosage:0.7 μg
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Administration:I.v. via tail vein; single dose; i.p.; single dose
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Result:Reduced N. meningitidis bacterial burden (luminescence photons/ROI) maximally at 24 h postinfection.
Decreased clinical disease signs (squinted eyes, ruffled fur, lethargy) at 24 h postinfection compared to vehicle controls.
化学情報
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CAS 番号 143-66-8
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性状 Solid
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分子量 342.22
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分子式 C24H20BNa
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Color White to off-white
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SMILES
[C-]1([B+3]([C-]2=CC=CC=C2)([C-]3=CC=CC=C3)[C-]4=CC=CC=C4)=CC=CC=C1.[Na+]
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別名
Sodium tetraphenylborate; Tetraphenylboron sodium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
溶剤 & 溶解度
DMSO : 200 mg/mL (584.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.33 mg/mL (9.73 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.9221 mL | 14.6105 mL | 29.2210 mL | 73.0524 mL |
| 5 mM | 0.5844 mL | 2.9221 mL | 5.8442 mL | 14.6105 mL | |
| DMSO | 10 mM | 0.2922 mL | 1.4610 mL | 2.9221 mL | 7.3052 mL |
| 15 mM | 0.1948 mL | 0.9740 mL | 1.9481 mL | 4.8702 mL | |
| 20 mM | 0.1461 mL | 0.7305 mL | 1.4610 mL | 3.6526 mL | |
| 25 mM | 0.1169 mL | 0.5844 mL | 1.1688 mL | 2.9221 mL | |
| 30 mM | 0.0974 mL | 0.4870 mL | 0.9740 mL | 2.4351 mL | |
| 40 mM | 0.0731 mL | 0.3653 mL | 0.7305 mL | 1.8263 mL | |
| 50 mM | 0.0584 mL | 0.2922 mL | 0.5844 mL | 1.4610 mL | |
| 60 mM | 0.0487 mL | 0.2435 mL | 0.4870 mL | 1.2175 mL | |
| 80 mM | 0.0365 mL | 0.1826 mL | 0.3653 mL | 0.9132 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2922 mL | 0.7305 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Kalibor 関連分類
HY-W025784 関連分類
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