KHK2805
KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human
KHK2805 (10 μg/mL; 1 h) binds strongly to the FOLR1-expressing human ovarian cancer cell lines IGROV1, OVMANA, SKOV3 and OVCAR3[1].
KHK2805 (0.1-10000 ng/mL; 2 h) induces complement-dependent cytotoxicity (CDC) against FOLR1-expressing human ovarian cancer cell lines IGROV1 and OVMANA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (C.B-17/Icr-scid/scid Jcl, female, 6 weeks old, Platinum (HY-W096169D)-resistant peritoneal dissemination and malignant ascites model induced by intraperitoneal inoculation of IGROV1 cells)[1]
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Dosage:0.1 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:i.v.; twice a week; once a week
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Result:Significantly reduced intraperitoneal tumor burden and eliminated detectable malignant ascites (10 mg/kg, twice a week).
Significantly reduced both intraperitoneal tumor burden and ascites volume (1 mg/kg, once a week).
Reduced tumor burden and ascites volume, with no statistically significant effects (0.1 mg/kg, once a week).
Significantly prolonged median survival.
FOLR1/FRA
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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SMILES
[KHK2805]
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別名
RA15-7, HuRA15-7Acc
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KHK2805 関連分類
HY-P992004 関連分類
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