KUS121
Based on 1 Customer Validation
KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 1357164-52-3
- 分子式: C22H16FN4NaO3S
- 分子量:458.44
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
KUS121 protects neurons from cell death under oxygen glucose deprivation (OGD) by preventing ATP depletion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KUS121 suppresses thinning of the outer nuclear layer and maintained visual function. KUS121 (retinas) suppresses endoplasmic reticulum stress, activates mammalian target of rapamycin and suppresses disease-associated apoptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1357164-52-3
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性状 Solid
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分子量 458.44
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分子式 C22H16FN4NaO3S
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Color Brown to reddish brown
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SMILES
O=S(C1=C2C=CC=CC2=C(N)C(/N=N/C3=CC=C(C4=CC=C(C=C4C)F)N=C3)=C1)(O[Na])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 58.33 mg/mL (127.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep. 2017 Mar 20:7:44873. [Content Brief]
[2]. Hisanori Kinoshita, et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9(1):11519. [Content Brief]
[3]. Tomoko Hasegawa, et al. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep. 2016 Aug 9:6:31184. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1813 mL | 10.9066 mL | 21.8131 mL | 54.5328 mL |
| 5 mM | 0.4363 mL | 2.1813 mL | 4.3626 mL | 10.9066 mL | |
| 10 mM | 0.2181 mL | 1.0907 mL | 2.1813 mL | 5.4533 mL | |
| 15 mM | 0.1454 mL | 0.7271 mL | 1.4542 mL | 3.6355 mL | |
| 20 mM | 0.1091 mL | 0.5453 mL | 1.0907 mL | 2.7266 mL | |
| 25 mM | 0.0873 mL | 0.4363 mL | 0.8725 mL | 2.1813 mL | |
| 30 mM | 0.0727 mL | 0.3636 mL | 0.7271 mL | 1.8178 mL | |
| 40 mM | 0.0545 mL | 0.2727 mL | 0.5453 mL | 1.3633 mL | |
| 50 mM | 0.0436 mL | 0.2181 mL | 0.4363 mL | 1.0907 mL | |
| 60 mM | 0.0364 mL | 0.1818 mL | 0.3636 mL | 0.9089 mL | |
| 80 mM | 0.0273 mL | 0.1363 mL | 0.2727 mL | 0.6817 mL | |
| 100 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5453 mL |
KUS121 関連分類
HY-138233 関連分類
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