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製品番号: HY-174412

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LC-PDin06

LC-PDin06 is a selective PRDX1 inhibitor with an IC₅₀ of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels.

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CAS 番号: 2027514-32-3
分子式: C₃₅H₄₇N₃O₃
分子量:557.77

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

LC-PDin06 構造式

CAS 番号: 2027514-32-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
Calculators
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生物活性

製品説明

IC₅₀ & Target

0.042 μM

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.37 μM Compound: CEL21	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]
MCF7	IC₅₀	1.84 μM Compound: CEL21	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]
PANC-1	IC₅₀	1.53 μM Compound: CEL21	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]

化学情報

CAS 番号 2027514-32-3
分子量 557.77
分子式 C₃₅H₄₇N₃O₃
SMILES

OC1=C(C)C2=CC=C3[C@@]4(C)CC[C@@]5(C)CC[C@@](C)(C(NCCCN6C=CN=C6)=O)C[C@]([H])5[C@@](C)4CC[C@](C)3C2=CC1=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.