country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-155851

Copy Link Print Information

Lepadin E

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 444914-19-6
分子式: C₂₆H₄₇NO₃
分子量:421.66

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lepadin E 構造式

CAS 番号: 444914-19-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

ACSL4

ACSL Family アイソフォーム固有の製品をすべて表示 :

ACSL4
ACSL5

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示 :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.93 μM Compound: Lepadin E	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HeLa	IC₅₀	2.67 μM Compound: Lepadin E	Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HepG2	IC₅₀	6.2 μM Compound: Lepadin E	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
L02	IC₅₀	18.72 μM Compound: Lepadin E	Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MCF7	IC₅₀	5.95 μM Compound: Lepadin E	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MDA-MB-231	IC₅₀	8.04 μM Compound: Lepadin E	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1155	IC₅₀	7.88 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1355	IC₅₀	8.8 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SH-SY5Y	IC₅₀	6.19 μM Compound: Lepadin E	Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SK-OV-3	IC₅₀	7.94 μM Compound: Lepadin E	Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SMMC-7721	IC₅₀	3.93 μM Compound: Lepadin E	Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]

化学情報

CAS 番号 444914-19-6
分子量 421.66
分子式 C₂₆H₄₇NO₃
SMILES

CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
- Marine natural products
- Other marine organisms
- Animals
Tropical Marine Tunicate Didemnum sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Lepadin E

ACSL Family アイソフォーム固有の製品をすべて表示

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Lepadin E 関連分類

HY-155851 関連分類