LI-3948
Based on 1 Customer Validation
LI-3948 is a blood-brain barrier-penetrant IP6K1 inhibitor with an IC50 of 16 nM. LI-3948 reduces locomotor activity and grooming behavior in mice and induces hypothermia. LI-3948 is a moderate P-glycoprotein efflux substrate, with low clearance in rodents and high plasma protein binding. LI-3948 can be used for central nervous system-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.85%
- CAS 番号: 3024591-38-3
- 分子式: C19H16Cl2FN3O3
- 分子量:424.25
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IP6K1 16 nM (IC50) |
体外実験
LI-3948 (Compound 29c) (30 min) is a potent IP6K1 inhibitor with an IC50 of 16 nM in the ADP-Glo enzymatic assay[1].
LI-3948 (5 μM; 120 min) is a moderate P-gp substrate in MDR1-MDCK cells, with an efflux ratio of 3.8 and an apical-to-basolateral Papp of 16 × 10−6 cm/s[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 8 weeks old)[1]
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Dosage:30 mg/kg
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Administration:p.o.; single dose
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Result:Locomotion was decreased relative to vehicle (t(12) = 2.562) and grooming was decreased (t(12.76) = 2.842).
Body temperature was uniformly and significantly decreased by roughly 3.5 °C measured 24 h after dosing.
Four mice, with similar exposure levels to the other six mice, exhibited locomotor activity similar to vehicle-treated mice.
No statistically significant decrease in IP7 levels in the brain was observed.
化学情報
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CAS 番号 3024591-38-3
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性状 Solid
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分子量 424.25
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分子式 C19H16Cl2FN3O3
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Color White to off-white
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SMILES
FC1=C(C(N)=O)C=CC(N2)=C1[C@]3(CC[C@H](OC4=NC=C(Cl)C=C4Cl)CC3)C2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (235.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (295 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3571 mL | 11.7855 mL | 23.5710 mL | 58.9275 mL |
| 5 mM | 0.4714 mL | 2.3571 mL | 4.7142 mL | 11.7855 mL | |
| 10 mM | 0.2357 mL | 1.1786 mL | 2.3571 mL | 5.8928 mL | |
| 15 mM | 0.1571 mL | 0.7857 mL | 1.5714 mL | 3.9285 mL | |
| 20 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9464 mL | |
| 25 mM | 0.0943 mL | 0.4714 mL | 0.9428 mL | 2.3571 mL | |
| 30 mM | 0.0786 mL | 0.3929 mL | 0.7857 mL | 1.9643 mL | |
| 40 mM | 0.0589 mL | 0.2946 mL | 0.5893 mL | 1.4732 mL | |
| 50 mM | 0.0471 mL | 0.2357 mL | 0.4714 mL | 1.1786 mL | |
| 60 mM | 0.0393 mL | 0.1964 mL | 0.3929 mL | 0.9821 mL | |
| 80 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7366 mL | |
| 100 mM | 0.0236 mL | 0.1179 mL | 0.2357 mL | 0.5893 mL |
LI-3948 関連分類
HY-162821 関連分類
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