LYP-IN-5
LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC50 value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases.
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- CAS 番号: 459853-10-2
- 分子式: C27H36N6O
- 分子量:460.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
LYP-IN-5 (Compound 4) (50 μM; 30-60 min) enhances the early TCR signaling pathway in JTAg-expressing human T cells and increases the phosphorylation levels of Lck Y394, ZAP70 Y319, ERK1/2, and SLP76 Y128[1].
LYP-IN-5 (50 μM) enhances TCR-induced phosphorylation of Lck Y394 and LAT Y191 in primary human T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat T antigen (JTAg) human T cell line
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Concentration:50 μM
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Incubation Time:30-60 min pre-incubation; 2 min TCR stimulation
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Result:Increased TCR-induced phosphorylation of Lck at Y394.
Increased TCR-induced phosphorylation of ZAP70 at Y319.
Increased TCR-induced phosphorylation of ERK1/2.
Increased TCR-induced phosphorylation of SLP76 at Y128.
化学情報
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CAS 番号 459853-10-2
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分子量 460.61
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分子式 C27H36N6O
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SMILES
O=C1NC2=C(C=C1C(N3CCCC4(CCCCC4)C3)C5=NN=NN5C6CCCC6)C=C(C)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LYP-IN-5 関連分類
HY-182299 関連分類
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