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製品番号: HY-121839

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Manoyl oxide

Manoyl oxide is a naturally occurring labdane-type diterpene with anticancer activity. Manoyl oxide is used in cancer-related research, such as breast cancer; it also serves as an intermediate for research related to organic synthesis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 596-84-9
分子式: C₂₀H₃₄O
分子量:290.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Manoyl oxide 構造式

CAS 番号: 596-84-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	100 μM	Antiproliferative activity against human HCT-116 colon cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human HCT-116 colon cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MCF7	IC50	50 μM	Antiproliferative activity against human MCF-7 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MCF-7 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MDA-MB-231	IC50	88 μM	Antiproliferative activity against human MDA-MB231 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MDA-MB231 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MDA-MB-468	IC50	88 μM	Antiproliferative activity against human MDA-MB468 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MDA-MB468 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298

体外実験

Manoyl oxide (compound 2) has an IC₅₀ value of 100 µM in HCT-116, 50 µM in MCF-7, 88 µM in MDA-MB231, and 88 µM in MDA-MB468^[1].
Manoyl oxide is detected in the leaf volatile oil of Rhododendron rufum; it is also detected in the leaf volatile oil of Rhododendron przewalskii^[2].
Manoyl oxide (compound A1) can serve as an intermediate, and its derivatives show no significant antiproliferative effect on KB, KB/VCR, K562, and K562/A02 tumor cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

化学情報

CAS 番号 596-84-9
分子量 290.48
分子式 C₂₀H₃₄O
SMILES

C[C@]12CCCC(C)([C@@]1(CC[C@@]3([C@@]2(CC[C@](C=C)(O3)C)[H])C)[H])C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gani I, et al. Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & Heck coupling on cytotoxicity. Natural product research. 2025 Oct;39(19):5452-5461.

[2]. Sang YL, et al. Investigation of insecticidal activity of two Rhododendron species on stored-product insects. Journal of Plant Diseases and Protection. 2023 Apr;130(2):371-82.

[3]. Nguyen TH, et al. Further terpenoids from Vitex negundo L. growing in Vietnam. Journal of Saudi Chemical Society. 2021 Aug;25(8):101298.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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