Melatonin-OH
Melatonin-OH is an oxidative Melatonin (HY-B0075) metabolite with free radical-scavenging activity. Melatonin-OH forms via Melatonin’s reaction with hydroxyl radicals (·OH). Melatonin-OH forms via Melatonin’s reaction with peroxynitrous acid or its activated form ONOOH.
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- 純度: 98.72%
- CAS 番号: 67199-08-0
- 分子式: C13H16N2O3
- 分子量:248.28
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Melatonin-OH (Cyclic 3-hydroxymelatonin) (3COHM) (5 μg/mL) can be accurately detected and quantified via optimized HPLC, with a measured concentration of 4.93 μg/mL for a 5 μg/mL standard solution and a retention time of 8.1 min with excellent peak resolution[1].
Cyclic 3-hydroxymelatonin (3COHM) (5 μg/mL) can be detected and quantified via optimized MEKC, with a measured concentration of 4.70 μg/mL for a 5 μg/mL standard solution, though results differ significantly from HPLC measurements[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 67199-08-0
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性状 Solid
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分子量 248.28
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分子式 C13H16N2O3
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Color White to off-white
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SMILES
O=C(C)N1CCC2(C3=CC(OC)=CC=C3NC12)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (402.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hevia D, et al. Development and validation of new methods for the determination of melatonin and its oxidative metabolites by high performance liquid chromatography and capillary electrophoresis, using multivariate optimization. J Chromatogr A. 2010;1217(8):1368-1374. [Content Brief]
[2]. Galano A, et al. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51(1):1-16. [Content Brief]
[3]. Reiter RJ, et al. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci. 2001 Jun;939:200-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0277 mL | 20.1386 mL | 40.2771 mL | 100.6928 mL |
| 5 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL | 20.1386 mL | |
| 10 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | 10.0693 mL | |
| 15 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 20 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL | 5.0346 mL | |
| 25 mM | 0.1611 mL | 0.8055 mL | 1.6111 mL | 4.0277 mL | |
| 30 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 40 mM | 0.1007 mL | 0.5035 mL | 1.0069 mL | 2.5173 mL | |
| 50 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0139 mL | |
| 60 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 80 mM | 0.0503 mL | 0.2517 mL | 0.5035 mL | 1.2587 mL | |
| 100 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0069 mL |
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