Metyrosine
Based on 1 Customer Validation
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.29%
- CAS 番号: 672-87-7
- 分子式: C10H13NO3
- 分子量:195.22
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
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Dosage:50, 100 or 200 mg/kg
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Administration:I.p.
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Result:Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 672-87-7
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性状 Solid
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分子量 195.22
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分子式 C10H13NO3
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Color White to off-white
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SMILES
C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1
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別名
α-メチル-L-チロシン; α-Methyl-L-p-tyrosine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
1 M HCl : 50 mg/mL (256.12 mM; Need ultrasonic)
H2O : 5 mg/mL (25.61 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [Content Brief]
[2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1 M HCl | 1 mM | 5.1225 mL | 25.6124 mL | 51.2248 mL | 128.0620 mL |
| 5 mM | 1.0245 mL | 5.1225 mL | 10.2450 mL | 25.6124 mL | |
| 10 mM | 0.5122 mL | 2.5612 mL | 5.1225 mL | 12.8062 mL | |
| 15 mM | 0.3415 mL | 1.7075 mL | 3.4150 mL | 8.5375 mL | |
| 20 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4031 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0490 mL | 5.1225 mL | |
| 1 M HCl | 30 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL |
| 40 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 50 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 60 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1344 mL | |
| 80 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 100 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Metyrosine 関連分類
HY-W015007 関連分類
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