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製品番号: HY-111282

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MK-789

MK-789 is a competitive reversible inhibitor of dehydropeptidase I (DHP-I). MK-789 competitively blocks the entry of N-formimidoylthienamycin into proximal tubular cells, thereby inhibiting its renal metabolism. MK-789 shifts the renal excretion pathway of N-formimidoylthienamycin to glomerular filtration only, increasing its urinary recovery rate and renal clearance. MK-789 is applicable to studies on renal metabolism and pharmacokinetics.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 85394-14-5
分子式: C₁₄H₂₃NO₃
分子量:253.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-789 構造式

CAS 番号: 85394-14-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Dipeptidyl Peptidase アイソフォーム固有の製品をすべて表示 :

体外実験

MK-789 and its oxidative metabolites inhibit purified dehydropeptidase I in spectrophotometric assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

MK-789 (25, 75, 150 mg; intravenous injection; single administration; 7-day washout period between each dose) increases the urinary recovery rate of co-administered 150 mg N-formimidoylthienamycin to a plateau value of approximately 61% in healthy Caucasian male subjects; it elevates the plasma AUC of co-administered N-formimidoylthienamycin by approximately 20% without altering its plasma half-life^[1].\n

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 85394-14-5
分子量 253.34
分子式 C₁₄H₂₃NO₃
SMILES

O=C(/C(NC(C1CC1(C)C)=O)=C\CCCCC)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Norrby SR, et al. Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors. Antimicrobial agents and chemotherapy. 1983 Feb;23(2):300-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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