MK204
MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1959605-73-2
- 分子式: C16H9Br5ClNO4
- 分子量:714.22
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 1959605-73-2
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性状 Solid
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分子量 714.22
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分子式 C16H9Br5ClNO4
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Color White to off-white
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SMILES
O=C(O)COC1=CC(Cl)=CC=C1C(NCC2=C(Br)C(Br)=C(Br)C(Br)=C2Br)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (140.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
純度とドキュメンテーション
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データシート (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4001 mL | 7.0006 mL | 14.0013 mL | 35.0032 mL |
| 5 mM | 0.2800 mL | 1.4001 mL | 2.8003 mL | 7.0006 mL | |
| 10 mM | 0.1400 mL | 0.7001 mL | 1.4001 mL | 3.5003 mL | |
| 15 mM | 0.0933 mL | 0.4667 mL | 0.9334 mL | 2.3335 mL | |
| 20 mM | 0.0700 mL | 0.3500 mL | 0.7001 mL | 1.7502 mL | |
| 25 mM | 0.0560 mL | 0.2800 mL | 0.5601 mL | 1.4001 mL | |
| 30 mM | 0.0467 mL | 0.2334 mL | 0.4667 mL | 1.1668 mL | |
| 40 mM | 0.0350 mL | 0.1750 mL | 0.3500 mL | 0.8751 mL | |
| 50 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.7001 mL | |
| 60 mM | 0.0233 mL | 0.1167 mL | 0.2334 mL | 0.5834 mL | |
| 80 mM | 0.0175 mL | 0.0875 mL | 0.1750 mL | 0.4375 mL | |
| 100 mM | 0.0140 mL | 0.0700 mL | 0.1400 mL | 0.3500 mL |
MK204 関連分類
HY-120208 関連分類
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