MK771
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 66537-55-1
- 分子式: C16H22N6O4S
- 分子量:394.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MK771 (10 ng-10 µg/mouse; i.c.v.) produces a hyperthermic response in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-30 g, male MF1 mice[1]
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Dosage:5 mg/kg
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Administration:I.p.
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Result:Induced blinking and forepaw licking in both acutely isolated and paired mice.
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Animal Model:20-30 g, male MF1 mice[1]
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Dosage:0.25-60 mg/kg
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Administration:I.p.
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Result:Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg.
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Animal Model:25-30 g, Male Swiss-Webster mice[2]
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Dosage:10 ng-10 µg/mouse
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Administration:I.c.v.
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Result:Produced a hyperthermic response for 4 h followed by a return to normal temperature.
化学情報
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CAS 番号 66537-55-1
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分子量 394.45
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分子式 C16H22N6O4S
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SMILES
O=C(N[C@H](C(N1CSC[C@@H]1C(N)=O)=O)CC2=CNC=N2)[C@@H](N3)CCCC3=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369(1):1-9. [Content Brief]
[2]. Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MK771 関連分類
HY-119174 関連分類
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