MM-401
Based on 1 publication(s) in Google Scholar
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1442106-10-6
- 分子式: C29H46N8O5
- 分子量:586.73
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MM-401
More
生物活性
Ki: < 1 nM (WDR5); IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KOPN-8 | GI50 |
29.73 μM
Compound: 3; MM-401
|
Growth inhibition of human KOPN8 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human KOPN8 cells assessed as reduction in cell viability after 3 days
|
[PMID: 26958703] |
| MOLM-13 | GI50 |
23.97 μM
Compound: 3; MM-401
|
Growth inhibition of human MOLM13 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human MOLM13 cells assessed as reduction in cell viability after 3 days
|
[PMID: 26958703] |
| MV4-11 | GI50 |
12.42 μM
Compound: 3; MM-401
|
Growth inhibition of human MV4-11 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human MV4-11 cells assessed as reduction in cell viability after 3 days
|
[PMID: 26958703] |
MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1].
MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32μM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1].
MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1].
MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1].
MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
-
Concentration:0, 20, 40 μM
-
Incubation Time:48 h
-
Result:Specifically induced apoptosis of MLL-AF9 cells.
-
Cell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
-
Concentration:10, 20, 40 μM
-
Incubation Time:48 h
-
Result:Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.
-
Cell Line:MLL-AF9 cells
-
Concentration:20 μM
-
Incubation Time:48 h
-
Result:Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
化学情報
-
CAS 番号 1442106-10-6
-
分子量 586.73
-
分子式 C29H46N8O5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics. [Abstract]2023 Sep 14;14(1):5685. PMID: 37709746
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MM-401 関連分類
HY-19554 関連分類
Powered by Bioz