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製品番号: HY-182684

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MMV675968

MMV675968 is an inhibitor of Acinetobacter baumannii dihydrofolate reductase (AbDHFR) with an IC₅₀ of 8.5 nM, and it exhibits selectivity against human DHFR. MMV675968 inhibits dihydrofolate reductase in Cryptosporidium, Plasmodium, and Escherichia coli, disrupting the thymidylate cycle and folate biosynthesis pathway. MMV675968 inhibits the growth of multiple A. baumannii strains, including clinical isolates and environmental isolates. MMV675968 is applicable to research related to A. baumannii infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 159308-73-3
分子式: C₁₇H₁₈ClN₅O₂
分子量:359.81

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MMV675968 構造式

CAS 番号: 159308-73-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	25 μM Compound: 48; MMV675968	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay	[PMID: 30647879]

体外実験

MMV675968 selectively inhibits A. baumannii DHFR but not human DHFR, with an IC₅₀ of 8.5 nM against A. baumannii DHFR and an IC₅₀ of 492.4 nM against human DHFR^[1].
MMV675968 (0.6-10 μM; 18 h) inhibits the growth of Acinetobacter baumannii (A. baumannii) strains Mahidol, Naval-81, H72721 and 3-137, with IC₅₀ values of 0.6-2.7 μM, IC₉₀ values of 0.7-3.9 μM, and MIC values of 1.6-10 μM^[1].
MMV675968 (10 μM; 18 h) inhibits the growth of E. coli PA414 surrogate cells expressing A. baumannii DHFR, but exerts no such effect on these cells expressing human DHFR^[1].
MMV675968 (10 μM; 90 min) inhibits endogenous DHFR activity in Acinetobacter baumannii strains Mahidol, Naval-81, H72721, and 3-137^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 159308-73-3
分子量 359.81
分子式 C₁₇H₁₈ClN₅O₂
SMILES

ClC1=C2C(N)=NC(N)=NC2=CC=C1CNC3=CC(OC)=CC=C3OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Songsungthong W, et al. Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase. Sci Rep. 2019;9(1):15625. Published 2019 Oct 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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