MRS4719
MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2840581-32-8
- 分子式: C26H13N5O3S.C6H15N
- 分子量:504.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
P2X Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
IC50: 0.503 μM (P2X4 receptor)[1]
体外実験
MRS4719 (compound 21u) (0.1, 0.3, 0.6, 1.0 and 3.0 μM; 15 min) inhibits P2X4R-mediated Ca2+ influx in primary human monocyte-derived macrophages.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:0.5, 1.5 and 3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Caused significant neuroprotection using total hemispheric infarct volume size at doses 1.5 and 3.0 mg/kg.
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Animal Model:Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:1.5 and 3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Did not improve motor coordination and balance as assessed using rotarod.
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Animal Model:Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Improved dose-dependently learning and memory after stroke and reached statistical significance at a dose of 3 mg/kg.
化学情報
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CAS 番号 2840581-32-8
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分子量 504.60
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分子式 C26H13N5O3S.C6H15N
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SMILES
CC[NH+](CC)CC.O=C(NC1=C2C=CC=CC2=CC=C1N3C4=CC(C([N-]5)=NOC5=S)=NC=C4)CC3=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MRS4719 関連分類
HY-151547 関連分類
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