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製品番号: HY-181840

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MU262

MU262 is a MUS81 inhibitor with an IC₅₀ value of 0.87 μM. MU262 directly inhibits the catalytic activity of MUS81 without interfering with DNA binding, induces genomic instability in tumor cells, and specifically inhibits the HR/BIR repair pathway. The combination of MU262 with Cisplatin (HY-17394) significantly enhances the chemotherapeutic killing effect. MU262 serves as a chemical biology tool for studying MUS81 function, and also acts as a lead compound for the development of anticancer therapies that exploit DNA repair defects in cancer cells.

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CAS 番号: 1846587-13-0
分子式: C₂₀H₁₅FN₆O
分子量:374.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MU262 構造式

CAS 番号: 1846587-13-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MU262 (0.5-5 μM; 0-72 h) inhibits break-induced replication in U2OS BIR-GFP cells with an IC₅₀ of 1.53 μM^[1].
MU262 (1-5 μM; 0-72 h) inhibits homologous recombination in U2OS DR-GFP cells^[1].
MU262 (3-12 μM; 48 h) induces micronucleus formation in U2OS cells^[1].
MU262 (72 h) induces persistent DNA damage in U2OS cells, an effect detectable by increased formation of γH2AX foci^[1].
MU262 (administered for 10-12 days) reduces the clonogenic survival rate of U2OS cells^[1].
MU262 (2-16 μM; 96-120 h) acts synergistically with Cisplatin (HY-17394) to reduce the viability of U2OS cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U2OS cells
Concentration:

2, 8, 16 μM (in combination with Cisplatin 0-5 μM)
Incubation Time:

96-120 h
Result:

Dose-dependently enhanced cisplatin-induced cytotoxicity, reducing cell viability more effectively than cisplatin alone.

化学情報

CAS 番号 1846587-13-0
分子量 374.37
分子式 C₂₀H₁₅FN₆O
SMILES

OC1=C(C2=NC3=CC=CC=C3N2)N=NC4=C(C5=CC=C(F)C=C5)C(CC)=NN41
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Prochazkova J, et al. Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells. J Med Chem. 2026;69(5):5350-5369. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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