Mudanpioside E
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 172705-25-8
- 分子式: C24H30O13
- 分子量:526.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Mudanpioside E (10.0-100.0 μM) potently inhibits IgE-mediated β-hexosaminidase release (a marker of degranulation) in RBL-2H3 cells, with an IC50 of 40.34 μM, and shows no cytotoxicity even at concentrations as high as 100.0 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY mice (6-week-old, male)[1]
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Dosage:0.55 mg/kg; 1.1 mg/kg; 2.2 mg/kg (all co-administered with Peony root-depleted Shoseiryuto-extract at 0.57 g/kg)
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Administration:p.o.; single dose
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Result:Significantly counteracted the suppressive effect of Peony root-depleted Shoseiryuto-extract on the PCA reaction in a dose-dependent manner at 0.55, 1.1, and 2.2 mg/kg.
Did not exhibit any effect on the PCA reaction when administered alone at 2.2 mg/kg.
化学情報
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CAS 番号 172705-25-8
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分子量 526.49
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分子式 C24H30O13
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SMILES
O=C(C1=CC(OC)=C(C=C1)O)OC[C@@]23[C@]4([C@]5(O[C@]2([H])O[C@@]([C@]3([H])C4)(C5)O)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tsukamoto K, et al. Counteractive effect of Paeonia lactiflora root constituent mudanpioside E against suppressive effect of Shoseiryuto-extract on passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2014;153(3):884-889. [Content Brief]
[2]. Shi YH, et al. Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora. J Nat Med. 2016;70(2):234-240. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Mudanpioside E 関連分類
HY-N18182 関連分類
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