NBC19
Based on 1 Customer Validation
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC50s of 80 nM and 850 nM, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.22%
- CAS 番号: 2068818-75-5
- 分子式: C24H26BCl3N2O2
- 分子量:491.65
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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NF-κB Signaling Compound Library
HY-L014
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Covalent Screening Library
HY-L036
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Antioxidant Compound Library
HY-L037
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Pain-Related Compound Library
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Membrane Receptor-targeted Compound Library
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Autoimmune Disease Compound Library
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Inflammasomes related Compound Library
HY-L175
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Radioprotector Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Pattern Recognition Receptors Library
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生物活性
化学情報
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CAS 番号 2068818-75-5
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性状 Solid
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分子量 491.65
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分子式 C24H26BCl3N2O2
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Color Light yellow to yellow
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SMILES
O=C(C)C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (203.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0340 mL | 10.1698 mL | 20.3397 mL | 50.8492 mL |
| 5 mM | 0.4068 mL | 2.0340 mL | 4.0679 mL | 10.1698 mL | |
| 10 mM | 0.2034 mL | 1.0170 mL | 2.0340 mL | 5.0849 mL | |
| 15 mM | 0.1356 mL | 0.6780 mL | 1.3560 mL | 3.3899 mL | |
| 20 mM | 0.1017 mL | 0.5085 mL | 1.0170 mL | 2.5425 mL | |
| 25 mM | 0.0814 mL | 0.4068 mL | 0.8136 mL | 2.0340 mL | |
| 30 mM | 0.0678 mL | 0.3390 mL | 0.6780 mL | 1.6950 mL | |
| 40 mM | 0.0508 mL | 0.2542 mL | 0.5085 mL | 1.2712 mL | |
| 50 mM | 0.0407 mL | 0.2034 mL | 0.4068 mL | 1.0170 mL | |
| 60 mM | 0.0339 mL | 0.1695 mL | 0.3390 mL | 0.8475 mL | |
| 80 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.6356 mL | |
| 100 mM | 0.0203 mL | 0.1017 mL | 0.2034 mL | 0.5085 mL |
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