NC9
Based on 1 publication(s) in Google Scholar
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible transglutaminase (TG) inhibitor. NC9 inhibits osteoblast differentiation and mineralization. NC9 destabilizes microtubules. NC9 can be used for the research of osteoblast differentiation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 1352090-52-8
- 分子式: C35H47N5O8S
- 分子量:697.84
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 NC9
More
生物活性
NC9 (50 μM; 12 days) reduces TG-activity down to 51% and decreases TG-mediated labeling of the cell layers[1]. NC9 (50 μM; 12 days) inhibits mineral depositions in osteoblast cultures and reduces Ca2+ accumulation in cell-matrix layer[1]. NC9 (50 μM; 12 days) blocks extracellular collagen type I (COL I) secretion and deposition, reduces fibronectin (FN) matrix formation and increases FN levels in the cytoskeleton and matrix fraction[1]. NC9 (50 μM; 12 days) destabilizes microtubules with the decreasing of plasma membrane 150-kDa Glu-tubulin level and increasing of 50-kDa tubulin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1352090-52-8
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性状 Solid
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分子量 697.84
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分子式 C35H47N5O8S
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Color Light yellow to yellow
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(C=C)=O)C(NCCOCCOCCNS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)=O
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別名
Cbz-Lys(Acr)-PEG2-dansyl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Lett
Transglutaminase 2 facilitates metastasis of basal-like bladder cancer by sustaining MVP-mediated MAPK/ERK1/2 signaling activation. [Abstract]2026 Jan 1:636:218146. PMID: 41238097
溶剤 & 溶解度
DMSO : 100 mg/mL (143.30 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (270 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4330 mL | 7.1650 mL | 14.3299 mL | 35.8248 mL |
| 5 mM | 0.2866 mL | 1.4330 mL | 2.8660 mL | 7.1650 mL | |
| 10 mM | 0.1433 mL | 0.7165 mL | 1.4330 mL | 3.5825 mL | |
| 15 mM | 0.0955 mL | 0.4777 mL | 0.9553 mL | 2.3883 mL | |
| 20 mM | 0.0716 mL | 0.3582 mL | 0.7165 mL | 1.7912 mL | |
| 25 mM | 0.0573 mL | 0.2866 mL | 0.5732 mL | 1.4330 mL | |
| 30 mM | 0.0478 mL | 0.2388 mL | 0.4777 mL | 1.1942 mL | |
| 40 mM | 0.0358 mL | 0.1791 mL | 0.3582 mL | 0.8956 mL | |
| 50 mM | 0.0287 mL | 0.1433 mL | 0.2866 mL | 0.7165 mL | |
| 60 mM | 0.0239 mL | 0.1194 mL | 0.2388 mL | 0.5971 mL | |
| 80 mM | 0.0179 mL | 0.0896 mL | 0.1791 mL | 0.4478 mL | |
| 100 mM | 0.0143 mL | 0.0716 mL | 0.1433 mL | 0.3582 mL |
NC9 関連分類
HY-129126 関連分類
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