NCT-504
Based on 1 Customer Validation
NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 1222765-97-0
- 分子式: C15H12N6O2S3
- 分子量:404.49
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Kinase Inhibitor Library
HY-L009
-
Metabolism/Protease Compound Library
HY-L012
-
Metabolic Enzyme Compound Library
HY-L146
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
生物活性
IC50: 15.8 μM (PIP4Kγ)[1]
NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate[1].
NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1].
NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration[1].
NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1].
NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs[1].
NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1].
NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1].
NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1].
NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293T cells
-
Concentration:5 μM, 10 μM
-
Incubation Time:2 hours, 6 hours
-
Result:Induced autophagosome formation.
化学情報
-
CAS 番号 1222765-97-0
-
性状 Solid
-
分子量 404.49
-
分子式 C15H12N6O2S3
-
Color White to light yellow
-
SMILES
CN1N=NN=C1SC2=C(C(C3=CC=CC(S(=O)(C)=O)=C3)=CS4)C4=NC=N2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (309.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (279 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4722 mL | 12.3612 mL | 24.7225 mL | 61.8062 mL |
| 5 mM | 0.4944 mL | 2.4722 mL | 4.9445 mL | 12.3612 mL | |
| 10 mM | 0.2472 mL | 1.2361 mL | 2.4722 mL | 6.1806 mL | |
| 15 mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 4.1204 mL | |
| 20 mM | 0.1236 mL | 0.6181 mL | 1.2361 mL | 3.0903 mL | |
| 25 mM | 0.0989 mL | 0.4944 mL | 0.9889 mL | 2.4722 mL | |
| 30 mM | 0.0824 mL | 0.4120 mL | 0.8241 mL | 2.0602 mL | |
| 40 mM | 0.0618 mL | 0.3090 mL | 0.6181 mL | 1.5452 mL | |
| 50 mM | 0.0494 mL | 0.2472 mL | 0.4944 mL | 1.2361 mL | |
| 60 mM | 0.0412 mL | 0.2060 mL | 0.4120 mL | 1.0301 mL | |
| 80 mM | 0.0309 mL | 0.1545 mL | 0.3090 mL | 0.7726 mL | |
| 100 mM | 0.0247 mL | 0.1236 mL | 0.2472 mL | 0.6181 mL |
NCT-504 関連分類
HY-136311 関連分類
Powered by Bioz