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United States

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製品番号: HY-P11837

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NECT-224

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₁₃H₁₅₃N₂₇O₃₃S₃
分子量:2513.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

NECT-224 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga^[1]^[2].

体外実験

NECT-224 binds to recombinant human nectin-4 with a dissociation constant of 1.64 nM, demonstrating high target affinity^[1].
NECT-224 binds to the Ig-like V domain of nectin-4, forming the basis for radiotracers enabling tumor imaging^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 2513.78
分子式 C₁₁₃H₁₅₃N₂₇O₃₃S₃
配列

NODAGA-Cys-Pro-{1Nal}-{d-Asp}-Cys-{Mox}-{hArg}-Asp-Trp-Ser-Thr-Pro-{Hyp}-Trp-Cys-NH2 (TATA?covalent?with?Cys1,Cys5,Cys15)
シーケンスの短縮

NODAGA-CP-{1Nal}-{d-Asp}-C-{Mox}-{hArg}-DWSTP-{Hyp}-WC-NH2 (TATA covalent with Cys1,Cys5,Cys15)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Krönke T, et al. "Precision on Two Wheels"─Structural Refinement of ⁶⁴Cu- and ⁶⁸Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application. J Med Chem. 2025;68(20):21962-21987. [Content Brief]

[2]. H Ou, et al. Cutting-edge advances in bicyclic peptide-based radiotracers for cancer imaging and theranostics. VIEW.2026, 7, 20250181.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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