Nelutroctiv
Based on 1 Customer Validation
Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- CAS 番号: 2299177-09-4
- 分子式: C24H22F5N3O4S
- 分子量:543.51
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
Nelutroctiv (1 μM) reduces the calcium concentration for 50% maximum tension (EC50) by 16%-25% and increases maximum tension (Tmax) by 16%-50% in permeabilized myocytes from human HFrEF, HFpEF (with or without severe obesity)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2299177-09-4
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性状 Solid
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分子量 543.51
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分子式 C24H22F5N3O4S
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Color White to off-white
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SMILES
O=C(C1=CN=CC(S(C)(=O)=O)=C1)N2[C@@]3([H])[C@](C[C@@H]2C(N[C@H](C4CC4)C5=C(C=C(C(F)=C5)C(F)(F)F)F)=O)([H])C3
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別名
CK-136
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (183.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8399 mL | 9.1995 mL | 18.3989 mL | 45.9973 mL |
| 5 mM | 0.3680 mL | 1.8399 mL | 3.6798 mL | 9.1995 mL | |
| 10 mM | 0.1840 mL | 0.9199 mL | 1.8399 mL | 4.5997 mL | |
| 15 mM | 0.1227 mL | 0.6133 mL | 1.2266 mL | 3.0665 mL | |
| 20 mM | 0.0920 mL | 0.4600 mL | 0.9199 mL | 2.2999 mL | |
| 25 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8399 mL | |
| 30 mM | 0.0613 mL | 0.3066 mL | 0.6133 mL | 1.5332 mL | |
| 40 mM | 0.0460 mL | 0.2300 mL | 0.4600 mL | 1.1499 mL | |
| 50 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9199 mL | |
| 60 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7666 mL | |
| 80 mM | 0.0230 mL | 0.1150 mL | 0.2300 mL | 0.5750 mL | |
| 100 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4600 mL |
Nelutroctiv 関連分類
HY-147292 関連分類
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