ニコチンヒドラジド
Based on 1 Customer Validation
Nicotinohydrazide (Nicotinic acid hydrazide) is a precursor used for synthesizing hydrazone derivatives with antibacterial and antifungal activities. Nicotinohydrazide can be used in studies of bacterial and fungal infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.35%
- CAS 番号: 553-53-7
- 分子式: C6H7N3O
- 分子量:137.14
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | CC50 |
153 μg/mL
Compound: 1h
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Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 25920564] |
| Vero | IC50 |
>73 μM
Compound: VI
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Trypanosomicidal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 transfected with beta-D-galactosidase infected in african green monkey Vero cells assessed as growth inhibition incubated 5 days prior to beta-D-galactopyranoside addition
Trypanosomicidal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 transfected with beta-D-galactosidase infected in african green monkey Vero cells assessed as growth inhibition incubated 5 days prior to beta-D-galactopyranoside addition
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[PMID: 23202852] |
Nicotinohydrazide-derived hydrazones (0.031-0.500 mg/mL; bacteria incubated at 37 °C for 24 h, fungi incubated at 30 °C for 1-7 days) possess broad-spectrum in vitro antibacterial and antifungal activities, produce inhibition zones of 22-28 mm against most tested pathogens except Salmonella typhi, reach a minimum MIC of 0.063 mg/mL against drug-resistant strains such as MRSA and VRE, and have a minimum MBC/MFC as low as 0.125 mg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 553-53-7
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性状 Solid
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分子量 137.14
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分子式 C6H7N3O
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Color White to light yellow
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SMILES
NNC(C1=CC=CN=C1)=O
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別名
ニコチン酸ヒドラジド; 3-Pyridinecarboxylic acid, hydrazide; Nicotinohydrazide; pyridine-3-carbohydrazide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 100 mg/mL (729.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2918 mL | 36.4591 mL | 72.9182 mL | 182.2955 mL |
| 5 mM | 1.4584 mL | 7.2918 mL | 14.5836 mL | 36.4591 mL | |
| 10 mM | 0.7292 mL | 3.6459 mL | 7.2918 mL | 18.2295 mL | |
| 15 mM | 0.4861 mL | 2.4306 mL | 4.8612 mL | 12.1530 mL | |
| 20 mM | 0.3646 mL | 1.8230 mL | 3.6459 mL | 9.1148 mL | |
| 25 mM | 0.2917 mL | 1.4584 mL | 2.9167 mL | 7.2918 mL | |
| 30 mM | 0.2431 mL | 1.2153 mL | 2.4306 mL | 6.0765 mL | |
| 40 mM | 0.1823 mL | 0.9115 mL | 1.8230 mL | 4.5574 mL | |
| 50 mM | 0.1458 mL | 0.7292 mL | 1.4584 mL | 3.6459 mL | |
| 60 mM | 0.1215 mL | 0.6077 mL | 1.2153 mL | 3.0383 mL | |
| 80 mM | 0.0911 mL | 0.4557 mL | 0.9115 mL | 2.2787 mL | |
| 100 mM | 0.0729 mL | 0.3646 mL | 0.7292 mL | 1.8230 mL |
Nicotinohydrazide 関連分類
HY-W012617 関連分類
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