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製品番号: HY-162313

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NIP-22c

NIP-22c is a novel coronavirus 3CL_pro inhibitor. The EC₅₀ for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2309384-85-6
分子式: C₃₂H₃₉N₅O₆
分子量:589.68

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NIP-22c 構造式

CAS 番号: 2309384-85-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NIP-22c is a novel coronavirus 3CL_pro inhibitor. The EC₅₀ for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	>100 μM Compound: 22c	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability	[PMID: 38432056]
Calu-3	CC₅₀	>100 μM Compound: 22c	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 38432056]
CCRF-CEM	CC₅₀	13.9 μM Compound: 22c	Cytotoxicity against human CEM cells assessed as reduction in cell viability Cytotoxicity against human CEM cells assessed as reduction in cell viability	[PMID: 38432056]
Huh-7	CC₅₀	32.7 μM Compound: 22c	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability	[PMID: 38432056]
PBMC	CC₅₀	30.9 μM Compound: 22c	Cytotoxicity against human PBMC cells assessed as reduction in cell viability Cytotoxicity against human PBMC cells assessed as reduction in cell viability	[PMID: 38432056]
Vero	CC₅₀	84.3 μM Compound: 22c	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	[PMID: 38432056]

化学情報

CAS 番号 2309384-85-6
分子量 589.68
分子式 C₃₂H₃₉N₅O₆
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](C[C@@H]1CCCNC1=O)C=O)=O)[C@@H](NC(C2=NOC(C)=C2)=O)CC3=CC=CC4=C3C=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Amblard F, et al. Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease. Eur J Med Chem. 2024 Feb 24;268:116263. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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