country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-162427

Copy Link Print Information

NMS-0963

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2765304-82-1
分子式: C₂₃H₂₉N₇O₃
分子量:451.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NMS-0963 構造式

CAS 番号: 2765304-82-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	27 nM Compound: 1; NMS-0963	Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
BaF3	IC₅₀	7827 nM Compound: 1; NMS-0963	Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
SU-DHL-6	IC₅₀	702.4 nM Compound: 1; NMS-0963	Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay	[PMID: 38604095]

化学情報

CAS 番号 2765304-82-1
分子量 451.52
分子式 C₂₃H₂₉N₇O₃
SMILES

CN1C(C(N[C@@H](C)CN2CCC2)=O)=CC(C3=CC=NC(NC4=CC(OC)=CC(OC)=C4)=N3)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

お問い合わせ在庫あり