NSC624206
Based on 1 Customer Validation
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation.
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- 純度: 98.4%
- CAS 番号: 13116-77-3
- 分子式: C19H33Cl2NS2
- 分子量:410.51
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: ~9 μM (ubiquitin E1)[1]
NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1].
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1].
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kip16 cells
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Concentration:10 nM-10 μM
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Incubation Time:24 hours
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Result:Induced accumulation of p27.
化学情報
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CAS 番号 13116-77-3
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性状 Solid
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分子量 410.51
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分子式 C19H33Cl2NS2
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Color White to off-white
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SMILES
CCCCCCCCCCNCCSSCC1=CC=C(Cl)C=C1.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NSC624206 関連分類
HY-103436 関連分類
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