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製品番号: HY-122176

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NU-7107

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ >10 μM. NU-7107 is applicable for cancer research.

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CAS 番号: 503465-21-2
分子式: C₁₈H₁₉N₃O₂
分子量:309.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NU-7107 構造式

CAS 番号: 503465-21-2

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ >10 μM. NU-7107 is applicable for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	3.25 μM Compound: 94	Inhibition of DNA dependent protein kinase isolated from HeLa cells Inhibition of DNA dependent protein kinase isolated from HeLa cells	[PMID: 15658870]

体外実験

NU7107 weakly inhibits DNA-PK with an IC₅₀ of >10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	V_d
Mice^[1]	20 mg/kg	i.p.	10390 nM	0.25 h	0.79 h	0.12 L

体内実験

NU-7107 (20 mg/kg; i.p.; single administration) exhibits significantly improved in vivo pharmacokinetic properties compared with NU7026 in female BALB/c mice, with a 4-fold lower plasma clearance rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female)^[1]
Dosage:

20 mg/kg
Administration:

i.p.; single dose
Result:

Reached a maximum plasma concentration (C_max) of 10390 nmol/L.
Reached time to maximum concentration (T_max) of 0.25 h.
Achieved area under the concentration vs time curve (AUC_last) of 12165 nmol·h/L.
Had a terminal half-life (t1/2) of 0.79 h.
Had plasma clearance (CI _obs.) of 0.11 L/h.
Had volume of distribution (V_d) of 0.12 L.
Remained detectable in plasma 6 hours post-administration.
Exhibited plasma clearance four-fold slower than that of NU7026.

化学情報

CAS 番号 503465-21-2
分子量 309.37
分子式 C₁₈H₁₉N₃O₂
SMILES

O=C1N2C(C=3C(C=C2)=CC=CC3)=NC(=C1)N4C[C@H](C)O[C@H](C)C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005;93(9):1011-1018. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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