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製品番号: HY-W714300

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Nuarimol

Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 63284-71-9
分子式: C₁₇H₁₂ClFN₂O
分子量:314.74

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nuarimol 構造式

CAS 番号: 63284-71-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Nuarimol (31.5-125 mg/kg; p.o.; once daily; for 1-5 consecutive days) induces dose-dependent, reversible hepatic effects in male Wistar rats, including increased p-nitroanisole O-demethylase activity, transient hepatocellular proliferation, and reversible hepatomegaly. Histological changes indicate that this is a regenerative response rather than a direct mitogenic response^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pzh:WIS (male, 200-210 g, acclimatized for 14 days under controlled environmental conditions)^[1]
Dosage:

31.5 mg/kg; 62.5 mg/kg; 125 mg/kg
Administration:

p.o.; once daily; 1, 3, or 5 consecutive days
Result:

Did not change liver weight.
Significantly increased p-nitroanisole O-demethylase activity.
Significantly increased the number of mitotic figures.
Observed cytoplasmic vacuolization (likely fatty changes) and focal hepatocyte destruction (suggesting piecemeal necrosis).

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

化学情報

CAS 番号 63284-71-9
分子量 314.74
分子式 C₁₇H₁₂ClFN₂O
SMILES

FC1=CC=C(C=C1)C(O)(C=2C=NC=NC2)C=3C=CC=CC3Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kostka G, et al. Early hepatic changes induced by nuarimol in rats. J Appl Toxicol. 1994;14(5):337-342. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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