OMDM169
OMDM169 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor with activity to increase 2-AG levels. OMDM169 exerts analgesic activity through indirect activation of cannabinoid receptors. The effective concentration of OMDM169 is 0.13 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 130193-44-1
- 分子式: C25H45NO5
- 分子量:439.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
2.8 μM
Compound: 8
|
Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting
Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting
|
[PMID: 18831576] |
| MDA-MB-435 | IC50 |
4.8 μM
Compound: 15g
|
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by Cell titer assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by Cell titer assay
|
[PMID: 18710210] |
化学情報
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CAS 番号 130193-44-1
-
分子量 439.63
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分子式 C25H45NO5
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SMILES
O=C(CNC=O)O[C@H](C[C@H](OC1=O)[C@@H]1CCCCCC)CCCCCCCCCCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)