OMTX005
Based on 1 Customer Validation
OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.44%
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保管条件:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Species Reactivity
Human
体外実験
OMTX005 specifically binds to FAP-expressing HT1080-FAP cells and primary CAF07 cells, with EC50 values of 76 pM and 130 nM, respectively[1].
OMTX005 (5 days) does not reduce the viability of HT1080-WT, HT1080-FAP or primary CAF07 cells[1].
OMTX005 (400 nmol/L; 0-48 h) does not induce caspase 3/7 activity in HT1080-WT, HT1080-FAP or primary CAF07 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080-WT, HT1080-FAP, primary CAF07 cells
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Concentration:up to 400 nmol/L
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Incubation Time:5 days
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Result:Did not exhibit cytotoxic activity in any of the cell lines tested.
遺伝子ID
アクセッション番号
Target
FAP
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human FAP Protein, Fc Tag, active dimer can bind OMTX005. The EC50 for this effect is 39.8 ng/mL.
化学情報
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[OMTX005]
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別名
OMTX705 antibody
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)