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製品番号: HY-P11870

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PADI4_7

PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to PADI4 but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular PADI4 from cell extracts for biochemical analyses, including the identification of PADI4-interacting proteins under resting or activated conditions.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₈₄H₁₁₀N₁₈O₁₉S
分子量:1707.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PADI4_7 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

PADI4

8 nM (Kd)

体外実験

PADI4_7 (30 μM) is an inert binder that does not modulate the catalytic activity of recombinant PADI4 in vitro^[1].
Biotinylated PADI4_7 (bio-PADI4_7) specifically enriches human PADI4 from lysates of mES cells stably expressing hPADI4, enabling the isolation of intracellular PADI4 for biochemical analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 1707.95
分子式 C₈₄H₁₁₀N₁₈O₁₉S
SMILES

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CSC7)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC8=CC=C(C=C8)O)NC7=O
配列

{dTyr}-Tyr-Pro-Lys-Gly-Ser-Trp-Gly-Tyr-Lys-Leu-Phe-Cys-Gly-NH2 (thioether bond:dTyr1-Cys13)
シーケンスの短縮

{dTyr}-YPKGSWGYKLFCG-NH2 (thioether bond:dTyr1-Cys13)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bertran MT, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. Nat Commun. 2024;15(1):9746. Published 2024 Nov 11. [Content Brief]

[2]. Bertran M T, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation[J]. BioRxiv, 2023: 2023.12. 12.571217.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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