PDE4B-IN-2
Based on 1 Customer Validation
PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.59%
- CAS 番号: 915082-52-9
- 分子式: C19H18ClN3O2S
- 分子量:387.88
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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PDE4B 15 nM (IC50) |
PDE4D 1.7 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| PBMC | IC50 |
0.5 M
Compound: 33
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Inhibition of LPS-induced TNFalpha production in mouse PBMCs
Inhibition of LPS-induced TNFalpha production in mouse PBMCs
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[PMID: 19447034] |
| Sf9 | IC50 |
32 nM
Compound: 16; CHEMBL1782306
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Inhibition of human N-terminal His6-tagged PDE4B1 catalytic domain (324 to 691 residues) expressed in baculovirus infected sf9 cells using cAMP as substrate preincubated for 15 mins followed by substrate addition measured for 10 mins in presence of NADH b
Inhibition of human N-terminal His6-tagged PDE4B1 catalytic domain (324 to 691 residues) expressed in baculovirus infected sf9 cells using cAMP as substrate preincubated for 15 mins followed by substrate addition measured for 10 mins in presence of NADH b
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[PMID: 26908025] |
PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 μM)[1].
PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC50=0.5 M)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 915082-52-9
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性状 Solid
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分子量 387.88
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分子式 C19H18ClN3O2S
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Color White to off-white
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SMILES
O=C(O)CC1=CC=C(NC2=NC(C3=CC=C(Cl)S3)=NC(C)=C2CC)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (64.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5781 mL | 12.8906 mL | 25.7812 mL | 64.4529 mL |
| 5 mM | 0.5156 mL | 2.5781 mL | 5.1562 mL | 12.8906 mL | |
| 10 mM | 0.2578 mL | 1.2891 mL | 2.5781 mL | 6.4453 mL | |
| 15 mM | 0.1719 mL | 0.8594 mL | 1.7187 mL | 4.2969 mL | |
| 20 mM | 0.1289 mL | 0.6445 mL | 1.2891 mL | 3.2226 mL | |
| 25 mM | 0.1031 mL | 0.5156 mL | 1.0312 mL | 2.5781 mL | |
| 30 mM | 0.0859 mL | 0.4297 mL | 0.8594 mL | 2.1484 mL | |
| 40 mM | 0.0645 mL | 0.3223 mL | 0.6445 mL | 1.6113 mL | |
| 50 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2891 mL | |
| 60 mM | 0.0430 mL | 0.2148 mL | 0.4297 mL | 1.0742 mL |
PDE4B-IN-2 関連分類
HY-115687 関連分類
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