Penicillinase
Based on 1 Customer Validation
Penicillinase is an enzyme capable of hydrolyzing penicillin. Penicillinase converts penicillin into penicilloic acid, which has no antigenicity, and destroys the antibacterial, antigenic and epileptogenic properties of penicillin. Penicillinase shortens the duration of penicillin-induced seizures and neutralizes the ability of penicillin to form epileptogenic foci. Penicillinase can be used in research related to penicillin hypersensitivity and penicillin-induced encephalopathy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9001-74-5
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
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Help & FAQs
生物活性
製品説明
体外実験
Penicillinase destroys penicillin in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
Topical administration of penicillinase prevents or eliminates penicillin-induced focal epileptogenic foci in acutely prepared adult cats without altering normal cortical electroencephalographic activity, but it has no effect on strychnine-induced epilepsy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (adult, epilepsy induced by intramuscular injection of 325,000 units/kg aqueous Na penicillin G)[2]
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Dosage:800,000 units
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Administration:i.v., over 2 minutes; i.m., single dose
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Result:Reduced frequency of penicillin-induced bilaterally synchronous 4- to 5-per-second spike-wave bursts and associated behavioral twitches, with complete disappearance by 3 hours after initial penicillin injection.
Eliminated penicillin-induced seizure activity without tachycardia or other side effects when administered i.m.
Shortened the duration of EEG abnormalities from at least six hours (untreated) to 3 hours.
EC Number
3.5.2.6
Enzyme Activity
≥120000 U/mL
Unit Definition
One unit is defined as the amount of enzyme required to hydrolyze one penicillin G per hour at 37ºC, pH 7.0
化学情報
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CAS 番号 9001-74-5
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[Penicillinase]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
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データシート (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
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- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Penicillinase 関連分類
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