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United States

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製品番号: HY-P10630

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Pep63

Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research.

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CAS 番号: 1781242-18-9
分子式: C₅₁H₈₇N₁₇O₁₃
分子量:1146.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pep63 構造式

CAS 番号: 1781242-18-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Pep63 can block the interaction of EphB2-ADDLs (Aβ-derived diffusible ligands) effectively and reverse impaired memory deficits in early AD mouse models by stereotactic administration into the dorsal hippocampus^[1].
Transferrin-liposome is a carrier for the delivery of Pep63 to the brain by transferrin receptor (TfR)-mediated transcytosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1781242-18-9
分子量 1146.34
分子式 C₅₁H₈₇N₁₇O₁₃
配列

Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala
シーケンスの短縮

VFQVRARTVA
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (258 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang X, et al. Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models. Cell Death Discov. 2021 Sep 21;7(1):256. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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