(+)-trans-C75
(+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent.
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- CAS 番号: 1234694-20-2
- 分子式: C14H22O4
- 分子量:254.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CPT-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
32.43 μM
Compound: 9, C75
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Inhibition of FASN in human A375 cells
Inhibition of FASN in human A375 cells
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[PMID: 21726077] |
| KB | IC50 |
36.5 μM
Compound: 55, C75
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Cytotoxicity in human KB cells
Cytotoxicity in human KB cells
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[PMID: 21504156] |
化学情報
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CAS 番号 1234694-20-2
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分子量 254.32
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分子式 C14H22O4
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SMILES
O=C([C@@H](C1=C)[C@@H](CCCCCCCC)OC1=O)O
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別名
(+)-C75
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rae C, et al. Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75. Chirality. 2017 Jan;29(1):10-13. [Content Brief]
[2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(+)-trans-C75 関連分類
HY-12364C 関連分類
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