Previtamin D3
Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1173-13-3
- 分子式: C27H44O
- 分子量:384.64
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保管条件:
-80°C, protect from light, stored under nitrogen
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Previtamin D3 undergoes temperature-dependent first-order interconversion with vitamin D3 in ethanol, with faster isomerization at higher temperatures[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Previtamin D3 (28-111 μg/1000 g consumed diet; p.o.; 7 doses at 3 to 4 day intervals) exhibits 35% of the antirachitic activity of pure vitamin D3 in rachitic North Holland Blue chicks, with this activity hypothesized to originate exclusively from vitamin D3 formed via in vivo isomerization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Vitamin-D-deficient rats[1]
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Dosage:0.2 J/cm2
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Administration:topical skin exposure; single dose
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Result:Identified radiolabeled previtamin D3 as the main photoproduct in UV-exposed skin extracts, with no vitamin D3 detected right after irradiation.
Verified previtamin D3 using mass spectrometry and UV spectroscopy, and validated its thermal conversion to vitamin D3 via characteristic spectral changes.
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Animal Model:North Holland Blue (1-day-old, mixed sex, weight-homogeneous groups, rachitogenic diet-induced rickets)[2]
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Dosage:28 μg/1000 g consumed diet; 44 μg/1000 g consumed diet; 70 μg/1000 g consumed diet; 111 μg/1000 g consumed diet
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Administration:p.o.; 7 doses at 3 to 4 day intervals
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Result:Recorded dose-dependent reductions in mean t.m.t.-distance values in chick assays, and displayed an antirachitic activity ratio of 0.35 (95% CI, 0.29-0.42) relative to pure vitamin D3.
化学情報
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CAS 番号 1173-13-3
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性状 Oil
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分子量 384.64
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分子式 C27H44O
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Color Colorless to light yellow
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SMILES
O[C@@H]1CC(/C=C\C2=CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]23[H])=C(C)CC1
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輸送条件
Shipping with dry ice.
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保管条件
-80°C, protect from light, stored under nitrogen
純度とドキュメンテーション
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データシート (271 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Previtamin D3 関連分類
HY-130705 関連分類
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