PT150
Based on 1 Customer Validation
PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.70%
- CAS 番号: 189035-07-2
- 分子式: C28H30O4
- 分子量:430.54
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Clinical Compound Library
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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HY-L086
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生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice (2.5 mg/kg/day rotenone by intraperitoneal injection for 14 days)[2]
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Dosage:30, 100 mg/kg
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Administration:P.o.; daily for 14 days
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Result:Reduced the loss of dopaminergic neuron (DAn) cell bodies in the substantia nigra (SN), but not the striatum, and prohibited intra-neuronal accumulation of α-synuclein (α-syn).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 189035-07-2
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性状 Solid
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分子量 430.54
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分子式 C28H30O4
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Color White to light yellow
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SMILES
O[C@]1(C#CC)[C@]2(C)[C@H]([C@H](CC3)C([C@@H](C4=CC5=C(C=C4)OCO5)C2)=C6C3=CC(CC6)=O)CC1
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別名
ORG-34517
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Morice C, et al. A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers. Sci Rep. 2021 May 10;11(1):9876. [Content Brief]
[2]. Latham AS, et al. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589261. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PT150 関連分類
HY-125558 関連分類
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