QO-40
Based on 1 Customer Validation
QO-40, a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs.
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- 純度: 98.77%
- CAS 番号: 1259536-70-3
- 分子式: C18H11ClF3N3O
- 分子量:377.75
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1.25 μM
Compound: 15
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Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
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[PMID: 21296466] |
QO-40 (100 μM) increases KCNQ2/3 currents in CHO cells. QO-40 potently augmentes KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO cells
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Concentration:100 μM
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Incubation Time:
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Result:Increased the amplitude of the activated outward current at 0 mV.
化学情報
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CAS 番号 1259536-70-3
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性状 Solid
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分子量 377.75
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分子式 C18H11ClF3N3O
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Color White to off-white
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SMILES
O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : ≥ 125 mg/mL (330.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology. 2011;87(5-6):297-310. [Content Brief]
[2]. Chang WT, et al. Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels. Pharmaceuticals (Basel). 2021 Apr 21;14(5):388. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6473 mL | 13.2363 mL | 26.4725 mL | 66.1813 mL |
| 5 mM | 0.5295 mL | 2.6473 mL | 5.2945 mL | 13.2363 mL | |
| 10 mM | 0.2647 mL | 1.3236 mL | 2.6473 mL | 6.6181 mL | |
| 15 mM | 0.1765 mL | 0.8824 mL | 1.7648 mL | 4.4121 mL | |
| 20 mM | 0.1324 mL | 0.6618 mL | 1.3236 mL | 3.3091 mL | |
| 25 mM | 0.1059 mL | 0.5295 mL | 1.0589 mL | 2.6473 mL | |
| 30 mM | 0.0882 mL | 0.4412 mL | 0.8824 mL | 2.2060 mL | |
| 40 mM | 0.0662 mL | 0.3309 mL | 0.6618 mL | 1.6545 mL | |
| 50 mM | 0.0529 mL | 0.2647 mL | 0.5295 mL | 1.3236 mL | |
| 60 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1030 mL | |
| 80 mM | 0.0331 mL | 0.1655 mL | 0.3309 mL | 0.8273 mL | |
| 100 mM | 0.0265 mL | 0.1324 mL | 0.2647 mL | 0.6618 mL |
QO-40 関連分類
HY-130070 関連分類
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