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United States

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製品番号: HY-153156

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R419

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1356629-00-9
分子式: C₃₃H₃₅N₅O₄
分子量:565.66

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

R419 構造式

CAS 番号: 1356629-00-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]
A549	IC₅₀	19.5 μM Compound: R419	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30001917]
C2C12	EC₅₀	0.23 μM Compound: 2, R419	Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	EC₅₀	0.03 μM Compound: 2, R419	Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	IC₅₀	2.817 μM Compound: 4; R419	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
HepG2	IC₅₀	5.2 μM Compound: R419	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30001917]
L02	IC₅₀	25.9 μM Compound: R419	Cytotoxicity against human L02 cells after 72 hrs by MTT assay Cytotoxicity against human L02 cells after 72 hrs by MTT assay	[PMID: 30001917]
NCI-H1299	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]

化学情報

CAS 番号 1356629-00-9
分子量 565.66
分子式 C₃₃H₃₅N₅O₄
SMILES

N#CC1=CC=C(CN2CCC(CC2)NC(C3=CN=C(C(N4CCC(CC4)C(C5=CC=C(C=C5)OC)=O)=O)C=C3)=O)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang Y, et al. Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2957-2960. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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