Rabdosin B
Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings.
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- CAS 番号: 84304-92-7
- 分子式: C24H32O8
- 分子量:448.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Rabdosin B (200 μM; 3-12 h) induces cell cycle retardation of the G2 phase and S phase in root meristematic cells. Rabdosin B shows a time- and dose-dependent increase in DNA damage[1].
Rabdosin B shows a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 μM) significantly promots root growth, but its higher levels at 120-200 μM, by contrast, has inhibitory effects. Additionally, all tested concentrations (10-40 μM) inhibits root hair development of seedlings in a dose-dependent manner[1].
Rabdosin B has cytotoxic against human tumour HepG2, GLC-82 and HL-60 cell lines with IC50 values of 8.95 μM, 4.47 μM and 10.22 μM, respectively[2].
Rabdosin B (6 μM, 9 μM, 12 μM, 15 μM; 24-48 hours) induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Root meristematic cells<
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Concentration:200 μM
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Incubation Time:3 h, 6 h, 9 h, and 12 h
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Result:Induced cell cycle retardation of the G2 phase and S phase.
化学情報
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CAS 番号 84304-92-7
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分子量 448.51
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分子式 C24H32O8
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SMILES
CC(OC[C@H](C1(C)C)[C@]([C@H](CC1)OC(C)=O)(COC2=O)[C@@]3([H])[C@]2(C(C4=C)=O)C[C@@]4([H])C[C@@H]3O)=O
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lan Ding, et al. Regulation of cell division and growth in roots of Lactuca sativa L. seedlings by the Ent-Kaurene diterpenoid rabdosin B. J Chem Ecol. 2010 May;36(5):553-63. [Content Brief]
[2]. Lan Ding, et al. Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant. Nat Prod Res. 2011 Sep;25(15):1402-11. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rabdosin B 関連分類
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