Retro-1
Retro-1 is a toxin inhibitor. Retro-1 blocks the retrograde transport of STxB to the trans-Golgi network/Golgi. Retro-1 inhibits the cytotoxic effects of Ricin, bacterial toxins Stx1 and Stx2. Retro-1 can also substantially enhance the effectiveness of antisense and splice switching oligonucleotides.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 313683-81-7
- 分子式: C18H17BrN2O2
- 分子量:373.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
6.2 μM
Compound: Retro-1; 6, mixture of enantiomers, mixture of conformers (1:1)
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Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by s
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by s
|
[PMID: 32648758] |
化学情報
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CAS 番号 313683-81-7
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分子量 373.24
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分子式 C18H17BrN2O2
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SMILES
O=C1NC2=CC=C(C=C2C(N(C1)C(CC)=O)C3=CC=CC=C3)Br
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Stechmann B, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. [Content Brief]
[2]. Ming X, et al. The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides. Nucleic Acids Res. 2013 Apr 1;41(6):3673-87. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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