Rooperol
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects.
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- CAS 番号: 83644-00-2
- 分子式: C17H14O4
- 分子量:282.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 83644-00-2
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分子量 282.29
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分子式 C17H14O4
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SMILES
OC1=CC=C(C=C1O)/C=C/CC#CC2=CC=C(C(O)=C2)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Boukes G J, et al. Rooperol as an antioxidant and its role in the innate immune system: An in vitro study[J]. Journal of ethnopharmacology, 2012, 144(3): 692-699. [Content Brief]
[2]. Kabanda M M. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study[J]. Chemical research in toxicology, 2012, 25(10): 2153-2166. [Content Brief]
[3]. Guzdek A, et al. Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages[J]. Mediators of Inflammation, 1997, 6(1): 53-57. [Content Brief]
[4]. Ali Azouaou S, et al. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells[J]. Investigational New Drugs, 2015, 33: 64-74. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rooperol 関連分類
HY-119666 関連分類
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