Rosonabant
Based on 1 Customer Validation
Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.68%
- CAS 番号: 861151-12-4
- 分子式: C21H21Cl3N4O
- 分子量:451.78
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 861151-12-4
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性状 Solid
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分子量 451.78
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分子式 C21H21Cl3N4O
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Color White to off-white
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SMILES
ClC1=CC=C(C2CC(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C=C4Cl)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 60 mg/mL (132.81 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2135 mL | 11.0673 mL | 22.1347 mL | 55.3367 mL |
| 5 mM | 0.4427 mL | 2.2135 mL | 4.4269 mL | 11.0673 mL | |
| 10 mM | 0.2213 mL | 1.1067 mL | 2.2135 mL | 5.5337 mL | |
| 15 mM | 0.1476 mL | 0.7378 mL | 1.4756 mL | 3.6891 mL | |
| 20 mM | 0.1107 mL | 0.5534 mL | 1.1067 mL | 2.7668 mL | |
| 25 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2135 mL | |
| 30 mM | 0.0738 mL | 0.3689 mL | 0.7378 mL | 1.8446 mL | |
| 40 mM | 0.0553 mL | 0.2767 mL | 0.5534 mL | 1.3834 mL | |
| 50 mM | 0.0443 mL | 0.2213 mL | 0.4427 mL | 1.1067 mL | |
| 60 mM | 0.0369 mL | 0.1845 mL | 0.3689 mL | 0.9223 mL | |
| 80 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.6917 mL | |
| 100 mM | 0.0221 mL | 0.1107 mL | 0.2213 mL | 0.5534 mL |
Rosonabant 関連分類
HY-14753 関連分類
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