S-15176
S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury.
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- CAS 番号: 148089-70-7
- 分子式: C31H48N2O4S
- 分子量:544.79
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 148089-70-7
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分子量 544.79
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分子式 C31H48N2O4S
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SMILES
OC1=C(C(C)(C)C)C=C(SCCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC)C=C1C(C)(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Albengres E, et al. S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes. Fundam Clin Pharmacol. 2001 Feb;15(1):41-6. [Content Brief]
[2]. Elimadi A, et al. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur J Pharmacol. 2003 May 9;468(2):93-101. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
S-15176 関連分類
HY-172227 関連分類
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