(S)-OTS514
(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.
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- CAS 番号: 1338541-25-5
- 分子式: C21H20N2O2S
- 分子量:364.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 1338541-25-5
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分子量 364.46
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分子式 C21H20N2O2S
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SMILES
O=C1NC2=C(C(C3=CC=C([C@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
DMSO : 31.43 mg/mL (86.24 mM; adjust pH to 3 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
[1]. Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. [Content Brief]
[2]. Stefka AT, et al. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models. Cancer Med. 2020 Jan;9(1):324-334. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7438 mL | 13.7189 mL | 27.4379 mL | 68.5946 mL |
| 5 mM | 0.5488 mL | 2.7438 mL | 5.4876 mL | 13.7189 mL | |
| 10 mM | 0.2744 mL | 1.3719 mL | 2.7438 mL | 6.8595 mL | |
| 15 mM | 0.1829 mL | 0.9146 mL | 1.8292 mL | 4.5730 mL | |
| 20 mM | 0.1372 mL | 0.6859 mL | 1.3719 mL | 3.4297 mL | |
| 25 mM | 0.1098 mL | 0.5488 mL | 1.0975 mL | 2.7438 mL | |
| 30 mM | 0.0915 mL | 0.4573 mL | 0.9146 mL | 2.2865 mL | |
| 40 mM | 0.0686 mL | 0.3430 mL | 0.6859 mL | 1.7149 mL | |
| 50 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3719 mL | |
| 60 mM | 0.0457 mL | 0.2286 mL | 0.4573 mL | 1.1432 mL | |
| 80 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8574 mL |
(S)-OTS514 関連分類
HY-18621B 関連分類
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