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製品番号: HY-181610

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SDH-IN-45

SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC₅₀ of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3112883-32-3
分子式: C₂₁H₁₆F₃NO₃
分子量:387.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SDH-IN-45 構造式

CAS 番号: 3112883-32-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SDH-IN-45 (compound 4i) (50 μg/mL) inhibits mycelial growth of multiple phytopathogenic fungi, with 75.0 ± 0.5% inhibition against Botrytis cinerea at 50 μg/mL^[1].
SDH-IN-45 inhibits Botrytis cinerea succinate dehydrogenase with an IC₅₀ of 5.97 μg/mL^[1].
SDH-IN-45 (7 μg/mL; mycelial growth period) causes morphological damage, including collapse and wrinkling, to Botrytis cinerea mycelia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SDH-IN-45 (compound 4i) (200 μg/mL) shows lower in vivo fungicidal activity against multiple crop fungal pathogens^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3112883-32-3
分子量 387.35
分子式 C₂₁H₁₆F₃NO₃
SMILES

O=C(C1=CC=CC=C1C(F)(F)F)NOCC2=CC=CC=C2OC3=CC=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sun Y, et al. Scaffold Hopping Combined with 3D-QSAR for the Discovery of Succinate Dehydrogenase Inhibitors Containing N-Benzyloxyformamide. J Agric Food Chem. 2026;74(5):4273-4281. [Content Brief]

Calculators

モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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